For mouse-controlled action games, I strongly prefer to use keyboard keys for actions and not mouse buttons. Constantly clicking and/or holding down mouse buttons gives me RSI in a hurry, and I also get less fine control of the mouse if I have to hold downward pressure on the buttons while moving it. Things go much better if I can lightly glide the mouse around with my right hand and do any keypresses with my left hand.
Aquaria
almost lets me do this. There are action keys for swim and fire. Unfortunately, the swim key only works for the speed burst you can do every second or so. It doesn't follow the mouse cursor around if you hold the key down.
I just bought this game, and I'd be much indebted to you if I could finish it without hand and forearm pain.
