This happens to me too. I'm only about four hours into the game and I've had six random crashes that happen just like those mentioned before (white screen, "nvdldlkdkmd blah blah" error). There seems to be no common factor in the crashes -- they can literally happen at any time, whether in the menus, looking at the map, exploring, etc. This doesn't ever occur with any of the FPS games I play, like TF2, CS:S, L4D.
My specs:
E6600 2.40 Ghz
GeForce 8800 GT (180.48 drivers)
3GB PC2-5300
Windows Vista Home Premium 32 bit
STEAM version of Aquaria, btw.