I know I've said this once, but I'll say it again: I honestly think this game would go well with the Nintendo DS. In games like
Lost Magic and
Tao's Adventure: Curse of the Demon Seal, the player has to make designs on the touch screen to cast spells and whatnot...couldn't the exact same thing be used for Aquaria?
If only I knew how many keyboard keys/mouse actions were actually needed to control/play this game, then we just may have a better understanding on what systems this game could go into.
If it's high on mouse control then the DS or Wii could be used, or there could be a spin wheel item screen (like in Sword of Mana) for other systems...
-BGS