Not totally certain, but it seems it may be a possibility, and chances are others have already realised this but thought I'd say anyway. Firstly, the problem is for some reoslutions on widescreen monitors, the game is off center and doesn't fit on the screen.
I just realised, using an Asus monitor (VW222U) it has an aspect control option which allows you to run a 4:3 game on the monitor using black bars on the side. Although this works in Aquaria for 1024*768 (which was never off center in the first place), it doesn't seem to work for the higher resolutions that are off center, instead the option is greyed out.
This option is ONLY greyed out when the monitor is already running in a widescreen resolution, hence even though I've selected a 4:3 resolution, Aquaria is NOT running at 4:3, it's still running widescreen but with the game window being displayed on the screen at 4:3, hence the reason the game isn't centered and is also off-screen. I think Aquaria may be forcing the monitor back to it's native res (1680*1050), while displaying the image in a portion of that space.
I don't know why aquaria is doing this, but if I'm right then I would assume there's something wrong with the way Aquaria is setting resolutions. Of course once the patch is released and proper 16:10 support is added this won't be a problem, but still, thought I'd throw this out there.
